Schofield Group

Chemistry Research Laboratory | Department of Chemistry

Dr Martine I. Abboud

Postdoctoral Researcher

Former DPhil Student at St John's College, Sir Hans Krebs Memorial Scholar (2013-2016)

Tel:+44 1865 275677
E-mail: martine.abboud@chem.ox.ac.uk

Research interests
Biochemical and biophysical studies of protein-protein/ligand interactions

 

Research Summary

My research has primarily focused on the use of nuclear magnetic resonance spectroscopy (NMR), and other biophysical techniques, to study the Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenases and the penicillin-binding proteins (PBPs) and β-lactamases. These enzymes are involved in clinically important biological processes, i.e. the hypoxic response and antimicrobial resistance, respectively. Both systems are interesting from an NMR perspective because of their dynamic loops involved in catalysis and relevant interactions with ligands. My work includes enzyme mechanistic studies, protein-protein/ligand interactions, protein conformational changes, and method development for inhibitor discovery.

 

Selected Publications

19F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase
Martine I. Abboud, Philip Hinchliffe, Jürgen Brem, Robert Macsics, Inga Pfeffer, Anne Makena, Klaus-Daniel Umland, Anna M. Rydzik, Guo-Bo Li, James Spencer, Timothy D. W. Claridge, Christopher J. Schofield, Angewandte Chemie International Edition, 2017

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors
Guo-Bo Li, Martine I. Abboud, Jürgen Brem, Hidenori Someya, Christopher T. Lohans, Sheng-Yong Yang, James Spencer, David W. Wareham, Michael A. McDonough, Christopher J. Schofield, Chemical Science, 2017

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Ya-Min Tian, Martine I. Abboud, Wei Ge, Carmen Domene, François-Xavier L. Cantrelle, Adam P. Hardy, Christopher W. Pugh, Peter J. Ratcliffe, Timothy D. Claridge, Christopher J. Schofield, Nature Communications, 2016

Interaction of Avibactam with Class B Metallo-β-lactamases
Martine I. Abboud, Christian Damblon, Jürgen Brem, Nicolas Smargiasso, Paola Mercuri, Bernard Gilbert, Anna M. Rydzik, Timothy D. W. Claridge, Christopher J. Schofield, Jean-Marie Frère, Antimicrobial Agents and Chemotherapy, 2016